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Transcriptional Vulnerabilities of Striatal Neurons in Human and Rodent Models of Huntington’s Disease
Matsushima, A., Pineda, S.S., Crittenden, J.R., Lee, H., Galani, K., Mantero, J., Tombaugh, G., Kellis, M., Heiman, M., and Graybiel, A.M. (2023) Nature Communications 14, 282.
A Partnership Between the Lipid Scramblase XK and the Lipid Transfer Protein VPS13A at the Plasma Membrane
Guillén-Samander, A., Wu, Y., Pineda, S.S., Garcia, F.J., Eisen, J.N., Leonzino, M., Ugur, B., Kellis, M., Heiman, M., and De Camilli, P. (2022) Proceedings of the National Academy of Sciences of the USA, 119(35):e2205425119.
Back-to-BACs in Huntington’s Disease Modeling
Lee, H. and Heiman, M. (2022). Neuron, 110(7):1087-1089.
Single-Cell Dissection of the Human Brain Vasculature
Garcia, F.J., Sun, N., Lee, H., Godlewski, B., Mathys, H., Galani, K., Zhou, B., Jiang, X., Ng, A.P., Mantero, J., Tsai, L.-H., Bennett, D.A., Sahin, M., Kellis, M. and Heiman, M. (2022). Nature, 603(7903):893-899.
An Amygdala Circuit That Suppresses Social Engagement
Kwon, J-T., Ryu, C., Lee, H., Sheffield, A., Fan, J., Cho, D.H., Bigler, S., Sullivan, H. A., Choe, H. K., Wickersham, I. R., Heiman, M., and Choi, G. B. (2021). Nature, 593(7857):114-118.
Shape Deformation Analysis Reveals the Temporal Dynamics of Cell-type-specific Homeostatic and Pathogenic Responses to Mutant Huntingtin
Megret, L., Gris, B., Nair, S.S., Cevost, J., Wertz, M., Aaronson, J., Rosinski, J., Vogt, T.F., Wilkinson, H., Heiman, M., Neri, C. (2021). eLife, 10:e64984.
Choroid Plexus NKCC1 Mediates Cerebrospinal Fluid Clearance During Mouse Early Postnatal Development
Xu, H., Fame, R.M., Sadegh, C., Sutin, J., Naranjo, C., Syau, D., Cui, J., Shipley, F.B., Vernon, A., Gao, F., Zhang, Y., Holtzman, M., Heiman, M., Warf, B.C., Lin, P.-Y, and Lehtinen, M.K. (2021). Nature Communications, 12(1):447.
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Lee, H., Fenster, R.J., Pineda, S.S.P., Gibbs, W.S., Mohammadi, S., Davila-Velderrain, J., Garcia, F.G., Therrien, M., Novis, H.S., Gao, F., Wilkinson, H., Vogt, T., Kellis, M, LaVoie, M.J., Heiman M. (2020). Neuron 107, 1-18.
Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
Roussarie, J-P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E.F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P.R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O.G., Greengard P. (2020). Neuron 107, 1-15.
Interleukin-6 Deficiency Exacerbates Huntington’s Disease Model Phenotypes
Wertz, M. H., Pineda, S. S., Lee H., Kulicke, R., Kellis, M., Heiman, M. (2020). Mol Neurodegener. 15(1):29.
Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
Wertz, M. H., Mitchem, M. R., Pineda, S. S., Hachigia, L. J. , Lee, H., Lau, V., Powers, A., Kulicke, R., Madan, G. K., Colic, M., Therrien, M., Vernon, A., Beja-Glasser, V. F., Hegde, M., Gao, F., Kellis, M., Hart, T., Doench, J. G., Heiman, M. (2020). Neuron 106, 1-14.
A Cortical-Brainstem Circuit Predicts and Governs Compulsive Alcohol Drinking
Siciliano, C.A., Noamany, H., Chang, C.-J., Brown, A.R., Chen, X., Leible, X., Lee J.J., Wang, J., Vernon, A.N., Vander Weele, C.M., Kimchi, E.Y., Heiman, M., and Tye, K.M. (2019). Science 366, 1008-1012.
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy
Dvela-Levitt, M., Kost-Alimova, M., Emani, M., Kohnert, E., Thompson, R., Sidhom, E.-H., Rivadeneira, A., Sahakian, N., Roignot, J., Papagregoriou, G., Montesinos, M.S., Clark, A.R., McKinney, D., Gutierrez, J., Rot,h M., Ronco, L., Elonga, E., Carter, T.A., Gnirke, A., Melanson, M., Hartland, K., Wieder, N., Hsu, J.C.H., Deltas, C., Hughey, R., Bleyer, A.J., Kmoch, S., Živná, M., Barešova, V., Kota, S., Schlondorff, J., Heiman, M., Alper, S.L., Wagner, F., Weins, A., Golub, T.R., Lander, E.S., and Greka, A. (2019). Cell 178, 521–535.
Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain
Sudmant, P.H., Lee, H., Dominguez, D., Heiman, M., and Burge. C,B. (2018). Cell Reports 9, 2447-2456.
Normal Aging Induces A1-like Astrocyte Reactivity
Clarke, L.E., Liddelow, S.A., Chakraborty, C., Münch, A.E., Heiman, M., and Barres, B.A. (2018). Proceedings of the National Academy of Sciences of the United States of America 115, E1896-E1905.
Control of Huntington’s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2
Hachigian, L.J., Carmona, V., Fenster, R.J., Kulicke, R., Heilbut, A., Sittler, A., Pereira de Almeida, L., Mesirov, J.P., Gao, F., Kolaczyk, E.D., and Heiman, M. (2017). Cell Reports 21, 2688-2695.
Identifying Novel Therapeutic Targets by Combining Transcriptional Data with Ordinal Clinical Measurements
Pirhaji, L., Milani, P., Dalin, S., Wassie, B.T., Dunn, D., Fenster, R.J., Avila-Pacheco, J., Greengard, P., Clish, C.B., Heiman, M., Lo, D., and Fraenkel, E. (2017). Nature Communications 8, 623.
Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell Type-Specific Level
Therrien, M. and Heiman, M. (2017). Neuron 95, 1232-1233.
Genome-Wide Genetic Screening in the Mammalian Central Nervous System
Wertz, M., and Heiman, M. Genome Editing in Neurosciences, Springer. In Press.
Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake
Li, Z., Kelly, L., Heiman, M., Greengard, P., and Friedman, J.M. (2016). Cell Metabolism 23, 945.
The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex
Nie, D., Chen, Z., Ebrahimi-Fakhari, D., Di Nardo, A., Julich, K., Robson, V.K., Cheng, Y.C., Woolf, C.J., Heiman, M., and Sahin, M. (2015). Journal of Neuroscience 35, 10762-72.
Protein Kinase A Directly Phosphorylates Metabotropic Glutamate Receptor 5 to Modulate its Function
Uematsu, K., Heiman, M., Zelenina, M., Padovan, J., Chait, B.T., Aperia, A., Nishi, A., and Greengard, P. (2015). Journal of Neurochemistry 132, 677-86.
Synthetic Lethal Screening in the Mammalian Central Nervous System Identifies Gpx6 as a Modulator of Huntington’s Disease
Shema, R., Kulicke, R., Cowley, G.S., Stein, R., Root, D.E., and Heiman, M. (2015) Proceedings of the National Academy of Sciences of the USA 112, 268-72.
Nitric Oxide Regulates Synaptic Transmission Between Spiny Projection Neurons
Sagi, Y., Heiman, M., Peterson, J.D., Musatov, S., Scarduzio, M., Logan, S.M., Kaplitt, M.G., Surmeier, D.J., Heintz, N., and Greengard, P. (2014) Proceedings of the National Academy of Sciences of the USA 111, 17636-41.
Cell Type-Specific Plasticity of Striatal Projection Neurons in Parkinsonism and L-DOPA-Induced Dyskinesia
Fieblinger, T., Graves, S.M., Sebel, L.E., Alcacer, C., Plotkin, J.L., Gertler, T.S., Chan, C.S., Heiman, M., Greengard, P., Cenci, M.A., and Surmeier, D.J. (2014). Nature Communications 5, 5316.
Cell Type-Specific mRNA Purification by Translating Ribosome Affinity Purification (TRAP)
Heiman, M., Kulicke, R., Fenster, R.J., Greengard, P., and Heintz, N. (2014) Nature Protocols 9, 1282-91.
Molecular Adaptations of Striatal Spiny Projection neurons During Levodopa-Induced Dyskinesia
Heiman, M., Heilbut, A., Francardo, V., Kulicke, R., Fenster, R.J., Kolaczyk, E.D., Mesirov, J.P., Surmeier, D.J., Cenci, M.A., and Greengard, P. (2014) Proceedings of the National Academy of Sciences of the USA. 111, 4578-83.
Differential Effects of Cocaine on Histone Posttranslational Modifications in Identified Populations of Striatal Neurons
Jordi, E., Heiman, M., Marion-Poll, L., Guermonprez, P., Cheng, S.K., Nairn, A.C., Greengard, P., and Girault, J.A. (2013) Proceedings of the National Academy of Sciences of the USA 110, 9511-6.
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death Under Irremediable ER Stress
Lerner, A.G., Upton, J.P., Praveen, P.V., Ghosh, R., Nakagawa, Y., Igbaria, A., Shen, S., Nguyen, V., Backes, B.J., Heiman, M., Heintz, N., Greengard, P., Hui, S., Tang, Q., Trusina, A., Oakes, S.A., and Papa, F.R. (2012) Cell Metabolism 16, 250-64.
Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice
Chan, C.S., Peterson, J.D., Gertler, T.S., Glajch, K.E., Quintana, R.E., Cui, Q., Sebel, L.E., Plotkin, J.L., Shen, W., Heiman, M., Heintz, N., Greengard, P., and Surmeier, D.J. (2012) Journal of Neuroscience 32, 9124-32.
Inhibition of mTOR Signaling in Parkinson’s Disease Prevents L-DOPA-Induced Dyskinesia
Santini, E., Heiman, M., Greengard, P., Valjent, E., and Fisone, G. (2009) Science Signaling 2, ra36.
L-DOPA Activates ERK Signaling and Phosphorylates Histone H3 in the Striatonigral Medium Spiny Neurons of Hemiparkinsonian Mice
Santini, E., Alcacer, C., Cacciatore, S., Heiman, M., Hervé, D., Greengard, P., Girault, J.A., Valjent, E., and Fisone, G. (2009) Journal of Neurochemistry 108, 621-33.
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
Heiman, M., Schaefer, A., Gong, S., Peterson, J.D., Day, M., Ramsey, K.E., Suárez-Fariñas, M., Schwarz, C., Stephan, D.A., Surmeier, D.J., Greengard, P., and Heintz, N. (2008) Cell 135, 738-48.
Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types
Doyle, J.P., Dougherty, J.D., Heiman, M., Schmidt, E.F., Stevens, T.R., Ma, G., Bupp, S., Shrestha, P., Shah, R.D., Doughty, M.L., Gong, S., Greengard, P., and Heintz, N. (2008) Cell 135, 749-62.
Regulation of Alzheimer’s Disease Amyloid-Beta Formation by Casein Kinase I
Flajolet, M., He, G., Heiman, M., Lin, A., Nairn, A.C., and Greengard, P. (2007) Proceedings of the National Academy of Sciences of the USA 104, 4159-64.
Mitogen-Activated Protein Kinase Stimulation of Ca(2+) Signaling is Required for Survival of Endoplasmic Reticulum Stress in Yeast
Bonilla, M. and Cunningham, K.W. (2003) Molecular Biology of the Cell 14, 4296-305.
Essential Role of Calcineurin in Response to Endoplasmic Reticulum Stress
Bonilla, M., Nastase, K.K. and Cunningham, K.W. (2002) EMBO Journal 21, 2343-53.
Subunit Organization in Cytoplasmic Dynein Subcomplexes
King, S.J., Bonilla, M., Rodgers, M.E., and Schroer. T.A. (2002) Protein Science 11, 1239-50.
Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
Bonilla, M. and Cunningham, K.W. (2002) Science Signaling 127, pe17.
A Homolog of Voltage-Gated Ca(2+) Channels Stimulated by Depletion of Secretory Ca(2+) in Yeast
Locke, E.G., Bonilla, M., Liang, L., Takita, Y., and Cunningham, K.W. (2000) Molecular and Cellular Biology 20(18),6686-94.