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Publications

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Resolving  CNS mRNA heterogeneity: examining mRNA alternative polyadenylation at a cell  type-specific level

Therrien M and Heiman M. Neuron.  In Press.

Identifying novel therapeutic targets by combining transcriptional data with ordinal clinical measurements

Pirhaji L, Milani P, Dalin S,  Wassie BT, Dunn D, Fenster RJ, Avila-Pacheco J, Greengard P,  Clish CB, Heiman M, Lo D and Fraenkel E.  Nature  Communications. In Press.

Genome-wide genetic screening in the mammalian central nervous system

Wertz M, and Heiman M.  Genome Editing in Neurosciences, Springer. In Press.

Hypothalamic amylin acts in concert with leptin to regulate food intake

Li Z, Kelly L, Heiman M, Greengard P and Friedman JM. Cell Metabolism. May 2016,  23:945, doi: 10.1016/j.cmet.2016.04.014.

The stress-induced Atf3-Gelsolin cascade underlies dendritic spine deficits in neuronal models of tuberous sclerosis complex

Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M and  Sahin M. Journal of Neuroscience. Jul 2015,  35:10762-72, doi: 10.1523/JNEUROSCI.4796-14.2015.

Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function

Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A and Greengard P.  Journal of Neurochemistry. Mar 2015,  132:677-86, doi: 10.1111/jnc.13038.

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease

Shema R, Kulicke R, Cowley GS, Stein R, Root DE and Heiman M.  Proceedings of the National Academy of Sciences of the USA. Jan 2015,  112:268-72, doi: 10.1073/pnas.1417231112.

Nitric oxide regulates synaptic transmission between spiny projection neurons

Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N and Greengard P.  Proceedings of the National Academy of Sciences of the USA.  Dec 2014,  111:17636-41, doi: 10.1073/pnas.1420162111.

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA and Surmeier DJ.  Nature Communications. Oct 2014,  5:5316, doi: 10.1038/ncomms6316.

Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP)

Heiman M, Kulicke R, Fenster RJ, Greengard P and Heintz N.  Nature Protocols. May 2014, 9:1282-91, doi: 10.1038/nprot.2014.085.

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA and Greengard P.  Proceedings of the National Academy of Sciences of the USA. Mar 2014,  111:4578-83, doi: 10.1073/pnas.1401819111.

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons

Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P and Girault JA.  Proceedings of the National Academy of Sciences of the USA. Jun 2013,  110:9511-6, doi: 10.1073/pnas.1307116110.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress

Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA and Papa FR.  Cell Metabolism. Aug 2012, 16:250-64, doi: 10.1016/j.cmet.2012.07.007.

Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice

Chan CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui Q, Sebel LE, Plotkin JL, Shen W, Heiman M, Heintz N, Greengard P andSurmeier DJ.  Journal of Neuroscience. Jul 2012, 32:9124-32, doi: 10.1523/JNEUROSCI.0229-12.2012.

Inhibition of mTOR signaling in Parkinson’s disease prevents L-DOPA-induced dyskinesia

Santini E, Heiman M, Greengard P, Valjent E and Fisone G.  Science Signaling. Jul 2009,  2:ra36, doi: 10.1126/scisignal.2000308.

L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

Santini E, Alcacer C, Cacciatore S, Heiman M, Hervé D, Greengard P, Girault JA, Valjent E and Fisone G.  Journal of Neurochemistry. Feb 2009,  108:621-33, doi: 10.1111/j.1471-4159.2008.05831.x.

A translational profiling approach for the molecular characterization of CNS cell types

Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Suárez-Fariñas M, Schwarz C, Stephan DA, Surmeier DJ, Greengard P and Heintz N. Cell. Nov 2008, 135:738-48, doi: 10.1016/j.cell.2008.10.028.

Application of a translational profiling approach for the comparative analysis of CNS cell types

Doyle JP, Dougherty JD, Heiman M, Schmidt EF, Stevens TR, Ma G, Bupp S, Shrestha P, Shah RD, Doughty ML, Gong S, Greengard P and Heintz N. Cell.Nov 2008, 135:749-62, doi: 10.1016/j.cell.2008.10.029.

Regulation of Alzheimer’s disease amyloid-beta formation by casein kinase I

Flajolet M, He G, Heiman M, Lin A, Nairn AC and Greengard P.  Proceedings of the National Academy of Sciences of the USA. Mar 2007, 104:4159-64, doi:10.1073/pnas.0611236104.

Mitogen-activated protein kinase stimulation of Ca(2+) signaling is required for survival of endoplasmic reticulum stress in yeast

Bonilla M and Cunningham KW. Molecular Biology of the Cell. Oct 2003,  14:4296-305, doi:  10.1091/mbc.E03-02-0113.

Essential role of calcineurin in response to endoplasmic reticulum stress

Bonilla M, Nastase KK and Cunningham KW.  EMBO Journal. May 2002,  21:2343-53, doi:  10.1093/emboj/21.10.2343.

Subunit organization in cytoplasmic dynein subcomplexes

King SJ, Bonilla M, Rodgers ME and Schroer TA.  Protein Science. May 2002,  11:1239-50, doi: 10.1110/ps.2520102.

Calcium release and influx in yeast: TRPC and VGCC rule another kingdom

Bonilla M and Cunningham KW.  Science Signaling. Apr 2002,  2002(127):pe17, doi:  10.1126/stke.2002.127.pe17.

A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast

Locke EG, Bonilla M, Liang L, Takita Y and Cunningham KW.  Molecular and Cellular Biology. Sep 2000,  20(18):6686-94,  doi:10.1128/MCB.20.18.6686-6694.2000.